The US Geological Survey said the quake hit with a magnitude of 7.4 in an isolated area near the Chinese border between the capital, Kathmandu, and Mount Everest.
It comes just two weeks after an earthquake killed more than 8,150 people and injured more than 17,860 as it flattened mountain villages and destroyed buildings.
In Kathmandu, the quake sent Nepalese people rushing out of their homes into the streets.
There were no immediate reports of damage.
The previous earthquake hit Nepal on 25 April and Islanders have since been carrying out a number of fundraisers to support those affected.
Following last month’s earthquake, the Jersey Overseas Aid Commission also pledged £90,000 emergency aid to the victims.
The British Red Cross, Oxfam and the Save the Children Fund each received £30,000 in funding from the commission to go towards their relief efforts.
Today’s quake was deeper than the one last month, coming from a depth of 11.5 miles (18.5km) compared with the previous quake, which hit 9.3 miles (15km).
More shallow earthquakes tend to cause more damage at the surface.
At least four people have been confirmed dead after the quake.
Strong shaking was also felt across northern India.
In the Indian capital of New Delhi, people scrambled outdoors while buildings swayed.
Though Islanders wouldn’t have experienced anything, this morning’s earthquake registered on a chart showing seismic activity in Jersey.
An official with the International Organisation for Migration said a number of buildings collapsed in the isolated town of Chautara after today’s earthquake, with at least four people killed.
IOM spokesman Paul Dillon said a search and rescue team had already begun searching through the wreckage of the little town.
Chautara has become a hub for humanitarian aid in the wake of the April 25 disaster, with dozens of aid workers now based there to send help deeper into the countryside.
