Thirty-two Palestinians have been wounded by Israeli fire during a mass protest along the beach near the Israeli frontier, Gaza’s Health Ministry said.
Protesters threw flaming tyres over the fence, while fishing boats hoisted Palestinian flags.
Israeli forces responded with tear gas and live fire.
It has intensified the protests in recent weeks as Egyptian-mediated ceasefire efforts have faltered.
Over the weekend, Israel halted Qatari-donated fuel shipments to Gaza’s power plant in response to the escalated protests.
Israel says it is defending its border.
An Israeli soldier was fatally shot in July.