The arrests were made after law enforcement officers searched a St Peter Port address, registered to several linked companies.
HM Revenue and Customs, the Cheshire Constabulary, the National Crime Agency and the Isle of Man carried out simultaneous searches of premises in Cheshire, London, Manchester and the Isle of Man.
A total of 13 premises were searched, including the one in Guernsey.
Led by HMRC, a total of six people have been arrested across the UK, Isle of Man and Guernsey.
Details of the companies and any connected individuals have not been released.
