Leeds found themselves on the end of a major FA Cup third-round giant-killing as they were stunned 3-0 by League Two Crawley.
Marcelo Bielsa’s side were reeling from two goals inside three second-half minutes from Nick Tsaroulla and Ashley Nadesan.
Leeds attempted to claw their way back into the game only for Jordan Tunnicliffe to finish them off with 20 minutes remaining and secure a memorable scalp for the Sussex club.
Tottenham came through their trip to eighth-tier minnows Marine unscathed, although Jose Mourinho’s side were given a fright before registering a 5-0 win.
With 20 minutes gone and the score goalless, Neil Kengni broke into the Spurs half and let fly from about 30 yards with a shot which crashed against Joe Hart’s crossbar.
Vinicius helped himself to two more and Lucas Moura chipped in before half-time with a sublime free-kick, with Alfie Devine becoming Spurs’ youngest ever player and goalscorer at 16 years and 163 days in the second half.
Brighton needed penalties to beat perennial giantkillers Newport after a 1-1 draw in Wales.
Solly March thought he had won it for the Seagulls in normal time with a 90th-minute strike from the edge of the box.
But Adam Webster scored a stoppage-time own-goal after a mistake by goalkeeper Jason Steele to take the tie to extra time.
Steele redeemed himself with a fine saves from Josh Sheehan, Mickey Demetriou, Liam Shephard and Scot Bennett in the shootout and Webster completed the salvation with the winning penalty.
There were comfortable wins for Chelsea and Manchester City.
Frank Lampard named a strong Blues side against League Two Morecambe as he attempted to kick-start their stuttering season.
And he was rewarded with goals from birthday boy Mason Mount, Timo Werner, Callum Hudson-Odoi and Kai Havertz in a 4-0 victory.
City also cruised into the fourth round as two goals from Bernardo Silva and a third from Phil Foden wrapped up a 3-0 win over Birmingham before half-time.
A superb Chris Martin strike gave Bristol City a 2-1 win over Portsmouth, Will Boyle’s extra-time header took Cheltenham through in a 2-1 victory over Mansfield, and Barnsley beat Tranmere 2-0 thanks to a goal from Michal Helik and a late Cauley Woodrow penalty.