Kevin De Bruyne faces a spell on the sidelines after suffering a knee injury in training with Manchester City.
The midfielder will undergo tests in the coming days to determine the full extent of the problem but there have been reports the 27-year-old could be sidelined for around two months.
A statement on the Premier League champions’ website read: “Kevin De Bruyne is undergoing tests on his right knee after sustaining an injury at training on Wednesday.
“The extent of the problem is not yet known and we will bring you further updates on Kevin’s condition in due course.”
De Bruyne, one of the stars of last season’s title success, only returned to full training last week after a delayed summer break following the World Cup.
The Belgium international featured as a second-half substitute in the league-opening win over Arsenal at the Emirates Stadium last Sunday.
City are next in action against Huddersfield at the Etihad Stadium on Sunday.
De Bruyne missed two months of the 2015-16 season – his first at City – after suffering knee ligament damage in a game against Everton.