Labour will promise to scrap business rates as part of a dramatic overhaul of the taxes paid by firms.
Shadow chancellor Rachel Reeves is set to announce that a Labour government would immediately cut the business tax, before eventually phasing it out completely.
But she will also commit to closing loopholes which allow some firms to avoid tax, promising to abolish measures which do not provide an economic benefit.
The move comes as Labour seeks to get its conference back on track following internal rows over party rules, criticism of Sir Keir Starmer after he ruled out nationalising energy giants and the fallout from Angela Rayner’s attack on the “scum” in Boris Johnson’s Cabinet.
Labour will focus on economic issues on Monday, with a focus on a looming cost of living crisis as well as Ms Reeves’ taxation reforms.
“The next Labour government will scrap business rates.
“We will carry out the biggest overhaul of business taxation in a generation, so our businesses can lead the pack, not watch opportunities go elsewhere.”
Ms Reeves will tell Labour’s conference in Brighton that the current business rates system punishes investment, entrepreneurship and the high street.
But she will also set her sights on the costly tax breaks offered to firms.
She will say: “There are hundreds of different tax breaks in the system.
“Some are important but too many simply provide loopholes for those who can afford the best advice.
“For businesses they create extra layers of complexity to navigate, and added together they cost more than our entire NHS budget.
“We will look at every single tax break. If it doesn’t deliver for the taxpayer or for the economy then we will scrap it.”
Labour’s business tax reform would look to shift the burden from the high street to online giants, and end the tax relief afforded to private schools due to their charitable status.
The party would also aim to raise £440 million by closing the carried interest loophole which relates to private equity fund managers and the share of profits made by investment deals.
Ms Reeves said: “Labour will tax fairly, spend wisely, and get our economy firing on all cylinders.”
National chair of the Federation of Small Businesses Mike Cherry said: “The shadow chancellor is right to propose concrete reform of a business rates tax which disproportionately burdens the small businesses and sole traders at the heart of local communities.”
He added: “Business rates is a regressive tax which hits firms before they’ve made a pound in turnover, let alone profit, whilst disincentivising sustainable investment.
“This proposal marks a welcome call to action that would take more small businesses out of the regressive rates system and rightly looks ahead to more fundamental reform.”
Tony Danker, CBI director-general, added: “Change to this outdated system is chronically overdue.
“The Labour Party should be applauded for grasping the nettle and putting forward a pro-growth, pro-investment package of reforms that will reflect our green ambitions, spur the economic recovery, and help level up our regions.”
Shadow work and pensions secretary Jonathan Reynolds will use his speech to highlight the combined impact of the imminent Universal Credit cut, rising energy bills and next April’s hike in national insurance.
Analysis from Labour indicated that the average working family will be more than £1,700 worse off by next April.
A working single parent with two children will lose 5% of their income this April because of the decision to freeze income tax personal allowances, raise national insurance and cut Universal Credit.
Ahead of his speech, Mr Reynolds said: “Working people in Britain are facing a perfect storm created by this Government which will see the average family nearly £2,000 a year worse off.
“Labour is on the side of working families, while the Conservatives are making their lives harder.
“It is not too late for the Government to change course, cancel their cut to Universal Credit and back struggling families this winter. Labour would maintain the uplift and replace Universal Credit.”
Conservative Party co-chairman Oliver Dowden dismissed Labour’s plans for the economy.
“Successive Labour leaders have threatened businesses with tax hikes, higher bills, and more red tape,” he said.
“Only the Conservatives can be trusted to support our businesses and help our economy thrive as we build back better”.