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Animal studies could help test for Covid-19 airborne transmission

UK News | Published:

The World Health Organisation has acknowledged there is ’emerging evidence’ that Covid-19 could be spread through particles in the air.

Placing hamsters on an aeroplane could be one way of examining whether coronavirus can be spread through airborne transmission, an infectious disease specialist has suggested.

Epidemiologist Professor David Heymann said further “complex studies” were needed to see if people could catch Covid-19 through air circulating on planes or through restaurant air conditioning systems.

He said scientists could use animal studies to test for the potential spread of the illness, an approach previously used for tuberculosis research.

Speaking at a Chatham House briefing on Wednesday, Prof Heymann argued that “epidemiological indicators” in some countries where people could move about in public did not point to an “increased transmission” that may occur if the virus was airborne.

More than 200 scientists wrote an open letter to the agency urging officials to recognise the possibility of airborne transmission of the virus.

Current guidelines from the WHO focus on the virus being spread primarily through droplets from the nose or mouth, which are expelled when an infected person coughs, sneezes or speaks.

The Geneva-based agency advises precautions to avoid these droplets, such as social distancing and regular hand washing.

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But signatories of the letter, published in the Clinical Infectious Diseases journal, have called on health officials to update guidance to include measures which would mitigate the risk of airborne transmission, such as providing sufficient ventilation, to minimise recirculating air, and avoiding overcrowding – particularly on public transport.

Prof Heymann said on Wednesday: “What we believe is that there is a possibility that there is this airborne transmission in enclosed spaces, that an air conditioning unit, especially one on the wall, might be able to pick up an aerosol, and then spit it back out, if it’s not filtered, into the room and circulated throughout the room.”

Another type of aerosolised transmission – airborne – could be where droplet particles are moved by other means such as air conditioning units.

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But he emphasised that the WHO was waiting to examine the results of ongoing studies in this area.

“One of these is to put an animal that can be infected with this virus into various places around rooms in hospitals or wherever, to see if those animals are being infected, and that’s being done with hamsters,” he said.

“In the past it was done for tuberculosis with guinea pigs, the hamsters can be infected with this virus, and there are actually cages sitting around in their various parts and experiments that are being done by academic institutions that will give us information as to whether or not this virus is spreading in aerosols, in airborne transmission.”

Asked if there was any evidence of airborne transmission occurring beyond theoretical studies, Prof Heymann said there was “some anecdotal evidence” of physically distanced people becoming infected in a restaurant in China.

“And one of the hypotheses is that this was the air conditioning unit,” he said.

Deaths involving Covid-19 in the UK
(PA Graphics)

He warned that if the virus was airborne, people’s eyes would be “even more at risk of being an entry point for the virus”.

But Prof Heymann, who works at the London School of Hygiene & Tropical Medicine, said people should not think that wearing a face mask would protect them outdoors from any type of infection, which could only be done through full personal protective equipment (PPE).

“The message is protecting yourself involves physical distancing. It involves hand washing, and it involves, when you can’t physical distance, wearing a mask to protect others,” he said.

He also argued: “If there is airborne transmission we need to better understand it before we can put interventions in place.”

Coronavirus graphic
(PA Graphics)

“And so, collecting that evidence over time, maybe doing experiments, maybe putting guinea pigs, or hamsters rather, on airplanes and flying them around with airborne transmission might be a way of showing those things, but these are complex studies which need to be developed in order to understand, and this is observation.”

He continued: “Observation will tell us now that airlines are flying again whether or not people are getting infected on airplanes, and it will tell us whether or not people are getting infected in spaced restaurants, in areas like that.”

He said SARS (severe acute respiratory syndrome) coronavirus did not transmit through circulating air, albeit had a different means of reproduction in the lungs, while tuberculosis does not transmit on aeroplanes.

Prof Heymann said that, in the absence of evidence of airborne transmission, individuals should choose to fly based on their own perception of risk and follow airline guidelines.

Prof Keith Neal, emeritus professor of the epidemiology of infectious diseases at the University of Nottingham, said separately on Wednesday: “Aerosol transmission cannot be ruled out but we need to know which routes – droplets, aerosols or surface contamination – are important as an infection risk.

“Until we do, social distancing, cough etiquette and hand washing remain important.

“We may move to more face coverings indoors but the evidence isn’t there yet.”

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